GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs7818688 | 1 | rs6989862 | chr8:96027568 | C8orf38 | chr8:95908040-96088396:+ | -0.25 | -4.26 | 2.48E-5 | Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia |
| THCA | cis | rs6472235 | 1 | rs6994725 | chr8:66844743 | PDE7A | chr8:66629906-66753755:- | 0.17 | 3.81 | 0.000156 | Myopia (pathological) |
| THCA | cis | rs1962772 | 1 | rs6997118 | chr8:17371403 | SLC7A2 | chr8:17354600-17428073:+ | -0.28 | -5.3 | 1.75E-7 | Plasma omega-6 polyunsaturated fatty acid levels (adrenic acid) |
| THCA | cis | rs1962772 | 1 | rs6997306 | chr8:17371520 | SLC7A2 | chr8:17354600-17428073:+ | -0.27 | -5.17 | 3.46E-7 | Plasma omega-6 polyunsaturated fatty acid levels (adrenic acid) |
| THCA | cis | rs1532423 | 1 | rs6997458 | chr8:86274030 | LRRCC1 | chr8:86019377-86058312:+ | 0.18 | 4.56 | 6.59E-6 | Blood trace element (Zn levels) |
| THCA | cis | rs428445 | 1 | rs6999 | chr20:55093901 | C20orf43 | chr20:55043647-55093942:+ | 0.28 | 7.51 | 2.95E-13 | Refractive astigmatism |
| THCA | cis | rs428445 | 1 | rs6999 | chr20:55093901 | CSTF1 | chr20:54967427-54979582:+ | 0.17 | 3.52 | 0.000478 | Refractive astigmatism |
| THCA | cis | rs1027730 | 1 | rs7000731 | chr8:94069301 | C8orf83 | chr8:93895865-94029901:- | 0.3 | 4.75 | 2.65E-6 | Attention deficit hyperactivity disorder |
| THCA | cis | rs2129782 | 1 | rs7000891 | chr8:89446259 | MMP16 | chr8:89049462-89339717:- | 0.33 | 5.31 | 1.72E-7 | Electrodermal activity |
| THCA | cis | rs2129782 | 1 | rs7001241 | chr8:89446459 | MMP16 | chr8:89049462-89339717:- | 0.33 | 5.31 | 1.72E-7 | Electrodermal activity |
| THCA | cis | rs10090774 | 1 | rs7001591 | chr8:141834000 | EIF2C2 | chr8:141541265-141645645:- | 0.12 | 3.55 | 0.00042 | Acute graft versus host disease in bone marrow transplantation (recipient effect) |
| THCA | cis | rs2129782 | 1 | rs7001875 | chr8:89446812 | MMP16 | chr8:89049462-89339717:- | 0.33 | 5.31 | 1.72E-7 | Electrodermal activity |
| THCA | cis | rs6988636 | 1 | rs7002021 | chr8:124185250 | FAM83A | chr8:124191287-124222317:+ | -0.34 | -4.19 | 3.33E-5 | Urinary uromodulin levels |
| THCA | cis | rs6988636 | 1 | rs7002332 | chr8:124185442 | FAM83A | chr8:124191287-124222317:+ | -0.34 | -4.19 | 3.33E-5 | Urinary uromodulin levels |
| THCA | cis | rs7818688 | 1 | rs7002940 | chr8:96027392 | C8orf38 | chr8:95908040-96088396:+ | -0.25 | -4.22 | 2.95E-5 | Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia |